Fine Mapping and Candidate Gene Analysis of Dravet Syndrome Modifier Loci on Mouse Chromosomes 7 and 8

Description

Fine Mapping of Dravet Syndrome Modifier Loci on Mouse Chromosomes 7 and 8. 

1. Hawkins2024_Dsm2_Dsm3_Survival.xlsx - Survival data used for mapping are contained in this workbook.
   1. Contents:
      1. Sheet 1: Dsm2 / Chromosome 7 Survival
         1. Column A: age at event (death or censoring)
         2. Columns B-J: event (1=death; 0=censored) by line
      2. Sheet 2: Dsm3 / Chromosome 8 Survival
         1. Column A: age at event (death or censoring)
         2. Columns B-J: event (1=death; 0=censored) by line
2. Hawkins2024_Dsm2b_SNPs.csv - C57BL/6J v 129S6/SvEvTac SNPs in Dsm2b (see below for column content)
3. Hawkins2024_Dsm2b_Indels.csv - C57BL/6J v 129S6/SvEvTac Indels in Dsm2b (see below for column content)
4. Hawkins2024_Dsm3_SNPs.csv -   C57BL/6J v 129S6/SvEvTac SNPs in Dsm3 (see below for column content)
5. Hawkins2024_Dsm3_Indels.csv - C57BL/6J v 129S6/SvEvTac Indels in Dsm3 (see below for column content)

• Column Descriptions for Files 2-5
  • Column A: Chr - Chromosome
  • Column B: Start (m39) - Start position in m39 Genome Assembly
  • Column C: End (m39) - End position in m39 Genome Assembly
  • Column D: Func - variant class
  • Column E: Gene - Gene symbol
  • Column F: Exonic|Biotype - variant type
  • Column G: Transcript - Trancript ID and variant
  • Column H: Codon_Change - the alternative codons with the variant base in upper case
  • Column I: Impact - the impact modifier for the consequence type
  • Column J: dbSNP - dbSNP ID
  • Column K: LOF|NMD - ratio of transcripts with loss of function or nonsense mediated decay
  • Column L: Chr Chromosome
  • Column M: Start (mm10) - Start position in mm10 Genome Assembly
  • Column N: End (mm10) - End position in mm10 Genome Assembly
  • Column O: Ref - Reference base
  • Column P: Obs - Alternate non-reference allele
  • Column Q: Otherinfo - zygosity
  • Column R: isoform - all transcripts

Additional details