The National Center for Data to Health (CD2H) was established through a 5-year award from the National Center for Advancing Translational Sciences (NCATS) and will coalesce and coordinate informatics activities across the Clinical and Translational Science Award (CTSA) Program, a network of more than 50 medical research institutions, to provide collaborative clinical and translational research infrastructure. The CD2H supports a vibrant and evolving collaborative informatics ecosystem for the CTSA Program and beyond. Collaborative innovation also serves as a strong foundation to support mechanisms to facilitate training, engagement, scholarly dissemination, and impact in translational science.