Published April 17, 2020
| Version v1.0.0
Masters Thesis
Open
The Association between Psychosocial Factors and Pro-Inflammatory Cytokines (IL-6 and IL-8) in Colorectal Cancer Patients
Creators
Abstract
Background: Colorectal cancer(CRC) is the third most common cancer among both men and women, and progression of CRC has been linked to pro-inflammatory states. Psychological factors, such as loneliness and poor social support, have been associated within creased serum levels of pro-inflammatory cytokines in a variety cancer cell types. Methods: As part of the Can Support pilot study, participants with newly diagnosed CRC provided blood samples and completed the PROMIS short form survey measures for social isolation, emotional support, companionship, informational support, and instrumental support prior to undergoing surgery. Serum IL-6 and IL-8 levels were determined via ELISA. Correlation as well as simple and multiple linear regression were used to assess the relationship between the serum cytokine levels and psychosocial factors.Results: From a total of 216 screened patients, complete data were obtained from 39 patients. The average age at diagnosis was 57.9years, and 51.3% were women. Due to protocol deviations, a total of 6 patients had blood drawn while in the OR as opposed to during standard pre-operative office visits. Average IL-6values trended towards significantly differing with respect to draw-time (p < 0.087). None of the five psychosocial variables correlated with normalized values of serum IL-6 or IL-8values. Simple linear regression models were created for each psychosocial and bio-marker pair, and none of the psychosocial variables significantly explained or correlated with either IL-6 or IL-8. Multivariate analysis with relevant covariates was completed for each psychosocial and bio-marker pair. Only instrumental support was identified as an independent predictor of IL-8 serum levels when adjusting for various covariates.Conclusion: There was little to no observed association between various social support measures and serum IL-6 or IL-8 levels, but the results do help to highlight the importance of protocol design, namely blood collection time, which helps to inform future trial design.Files
WalkerMargaret_86382_8533330_CE_Final_Walker.pdf
Files
(293.9 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:393d5fe14ca5a83fd28b1fba7b377f7e
|
293.9 kB | Preview Download |
Additional details
Dates
- Created
-
2020-04-17When the item was originally created.