Mental health and substance use disorders and care in individuals with sickle cell disease or trait: A scoping review protocol

Abstract (English)

Background: As a genetic disorder associated with multiple chronic medical comorbidities, individuals with sickle cell disease (SCD) or sickle cell trait (SCT) are reported to have negative mental health outcomes. The different genetic variations of SCD/SCT are associated with various rates and onset of medical comorbidities, which may lead to different rates or severity of comorbid mental health conditions.

Objective: The goal of this scoping review is to elucidate the association between SCD/SCT and mental health conditions, the underlying mechanisms, and existing mental health care management strategies for individuals with SCD/SCT.

Methods: This scoping review follows the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) published in 2018.